The U.S./Mexican boarder is the international boundary between The United States of America in the north and Mexico in the south.
Pre-Apocalypse
The U.S./Mexican border was the most crossed, controlled international border in the world, with some 350 million (legal) crossing every year. It spans a length of 1,989 miles and crosses everything from uninhabited dessert to major metropolitan areas.
Post-Apocalypse
The border seems to have been a hotbed of activity during the outbreak. According to George Geary, elements of the Mexican Military were deployed to secure to border and to stop the infected (and living refugees) from crossing into Mexico from America. At the time Madison's Group cross into Mexican waters aboard The Abigail, only elements of the Mexican Navy were operational in Baja California.
According to Sierra, the border was a nexus of activity, with people fleeing both south and north in order to escape the Infected. Sierra's traveling companion Gabi claims to know a safe haven in Mexico, which makes the border the destination for Gabi and Sierra. Gabi's boyfriend Colton knows about a tunnel under the border, which is the intended destination for Gabi and Sierra.
Also, when we last see Nicholas Clark and Ofelia Salazar, they were both (separately) at the U.S./Mexican border. They were attacked by members of a Militia on the American side of the border.
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