Kirkman published Battle Pope in 2000, in 2008 he became a partner at Image Comics and in 2010 opened Skybound. Skybound is his own imprint at Image Comics, which publishes his titles as well as other original work. In 2010 Kirkman also became executive producer, and writer of The Walking Dead on AMC.
Kirkman will serve as executive producer for the Skybound title Clone, written by David Schulner, which is in development as a television show at Universal.
In 2015 Skybound completed production on the feature film, Air, starring Norman Reedus (The Walking Dead) and Djimon Hounsou (Blood Diamond, In America).